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il2 promoter reporter cell line  (BPS Bioscience)


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    BPS Bioscience il2 promoter reporter cell line
    Il2 Promoter Reporter Cell Line, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/il2+promoter+reporter+cell+line/NF-%CE%BAB+Luciferase+Reporter+(Luc)+-+Jurkat+Recombinant+Cell+Line/pm38528120-222-7-15
    Average 94 stars, based on 13 article reviews
    il2 promoter reporter cell line - by Bioz Stars, 2026-10
    94/100 stars

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    other:

    Article Title: Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation.
    Article Snippet: Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication.. Small molecules targeting XPO1 induce cytotoxicity, and selinexor was approved by the Food and Drug Administration in 2019 as a cancer chemotherapy for relapsed multiple myeloma.. Here, we describe a cell-type-dependent chromatin-binding function for XPO1 that is essential for the chromatin occupancy of NFAT transcription factors and thus the appropriate activation of T cells.



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    il2 promoter luc pcdna  (BPS Bioscience)
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    (A) Jurkat <t>IL2-reporter</t> T cells expressing KIR3DL3 were co-cultured with CHO cells expressing anti-CD3 scFV, CHO cells coexpressing anti-CD3 scFV and HHLA2, or untransfected CHO cells in the presence or absence of CD28 mAb as indicated. <t>Luciferase</t> <t>activity</t> represented as relative light units (RLU). (B, C) Jurkat IL2-reporter T cells expressing KIR3DL3 were co-cultured with CHO cells coexpressing anti-CD3 scFV and HHLA2 in the presence of CD28 mAb and (B) HHLA2 mAbs or (C) KIR3DL3 mAbs. Fold activation of IL2 reporter luciferase activity is presented as mean ± S.D. (n≥3; **** P≤0.0001).
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    (A) Jurkat IL2-reporter T cells expressing KIR3DL3 were co-cultured with CHO cells expressing anti-CD3 scFV, CHO cells coexpressing anti-CD3 scFV and HHLA2, or untransfected CHO cells in the presence or absence of CD28 mAb as indicated. Luciferase activity represented as relative light units (RLU). (B, C) Jurkat IL2-reporter T cells expressing KIR3DL3 were co-cultured with CHO cells coexpressing anti-CD3 scFV and HHLA2 in the presence of CD28 mAb and (B) HHLA2 mAbs or (C) KIR3DL3 mAbs. Fold activation of IL2 reporter luciferase activity is presented as mean ± S.D. (n≥3; **** P≤0.0001).

    Journal: Cancer immunology research

    Article Title: KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1

    doi: 10.1158/2326-6066.CIR-20-0315

    Figure Lengend Snippet: (A) Jurkat IL2-reporter T cells expressing KIR3DL3 were co-cultured with CHO cells expressing anti-CD3 scFV, CHO cells coexpressing anti-CD3 scFV and HHLA2, or untransfected CHO cells in the presence or absence of CD28 mAb as indicated. Luciferase activity represented as relative light units (RLU). (B, C) Jurkat IL2-reporter T cells expressing KIR3DL3 were co-cultured with CHO cells coexpressing anti-CD3 scFV and HHLA2 in the presence of CD28 mAb and (B) HHLA2 mAbs or (C) KIR3DL3 mAbs. Fold activation of IL2 reporter luciferase activity is presented as mean ± S.D. (n≥3; **** P≤0.0001).

    Article Snippet: Jurkat cells (clone E6–1) expressing IL2_promoter Luc_pcDNA (BPS Bioscience; cat. #60481) were transfected with KIR3DL3 (pEF-Puro) by electroporation.

    Techniques: Expressing, Cell Culture, Luciferase, Activity Assay, Activation Assay